May 2019 By PsychDB.com

Gabapentin

Gabapentin (Tradename: Neurontin) is an anticonvulsant. It is structurally similar to GABA but does not directly bind to GABA receptors.

  • Alpha 2 Delta (α2δ) Ligand like Pregabalin
  • Tmax = 2-4 hours
  • Half-life = 5-7 hours

Insomnia: 100-900mg

Gabapentin is an approved treatment as an adjunctive therapy in the management of epilepsy. However, it is most commonly prescribed off-label for other conditions, including anxiety, alcohol use disorder, and chronic pain.[1] Gabapentin misuse is increasing. oral, intranasal, and intravenous). Misuse can produce anxiolytic effects and a euphoria that is similar opioid misuse. Gabapentin can cause respiratory depression, physiologic dependence, and withdrawal symptoms on cessation (including diaphoresis, anxiety, confusion, and seizures). Patients who are co-prescribed gabapentin and opioids are at a significantly higher risk of death compared with those prescribed opioids alone.[2]

Research