Vyvanse® (lisdexamfetamine)

Lisdexamfetamine (Trade name: Vyvanse®) is a stimulant medication in the amphetamine class primarily used in the treatment of attention-deficit/hyperactivity disorder (ADHD). Lisdexamfetamine is a substituted amphetamine and an inactive prodrug of dextroamphetamine.

  • Lasts 13-14 hours
  • The drug ingested is a pro-drug (inactive product) lisdexamfetamine dimesylate (i.e. - lysine is attached to lisdexamfetamine)
    • Whereas other long-acting stimulants achieve extended duration of action through “engineering,” Vyvanse achieves this through chemical conversion (hydrolysis of the covalent bond between L-lysine and d-amphetamine)
    • There is no abuse potential because of this mechanism, as first-pass metabolism is the rate-limiting step.
  • Lisdexamfetamine dimesylate is is converted in the serum to L-lysine (a naturally occurring amino acid) and pharmacologically active d-amphetamine
  • Capsules may be opened up and the powder inside (taste is slightly sweet) can be mixed into water, orange juice, or yogurt.