Single-Photon Emission Computed Tomography (SPECT)

Single Photon Emission Computed Tomography (SPECT) is a neuroimaging technique that uses a combination of computed tomography (CT) and a radioactive material (tracer) to measure regional cerebral blood flow in the brain. SPECT are typically ordered to look for areas of hypoperfusion in the brain.

  • SPECT is a nuclear imaging modality that measures radioactivity of gamma rays emitted from radioactive compounds bound to tracers.
  • SPECT is often ordered to look for regional changes in blood flow, which may suggest and underlying neurodegenerative etiology.

SPECT Findings and Neurodegenerative Disorders

Alzheimer's Dementia (AD) Medial temporal parietal hypo-perfusion is be suggestive of AD
Parkinson's Disease (PD)/Lewy Body Dementia Tend to have parietal-occipital distribution of hypo-perfusion (although the absence of this still does not rule out PD or DLB either.