Citalopram (Trade name: Celexa) is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class commonly used in the treatment of major depressive disorder.
| Substrate of (Metabolized by) | |
|---|---|
| Induces | |
| Inhibits |
| Population | Citalopram | Escitalopram |
|---|---|---|
| Adult 18-65 years without risk factors | • Starting: 20mg • Maximum: 40mg | • Starting: 10mg • Maximum: 20mg |
| Adult >65 years or impaired hepatic function | • Starting: 10mg • Maximum: 20mg | • Starting: 5mg • Maximum: 10mg |
| Taking omeprazole* | • Starting: 20mg • Maximum: 20mg | • Starting: 5mg • Maximum: 10mg |
| Starting | 10 mg PO daily for 2 weeks |
|---|---|
| Titration | Increase by 10 mg every 1 to 2 weeks depending on tolerability |
| Maximum | 40 mg (previously approved for up to 60 mg/day, but no longer due to QTc concerns) |
| Taper | Tapering/Switching Antidepressants |
Citalopram is linked to QTc prolongation. It is thought that SERT-R is the cause of QTc prolongation in dose dependent fashion