Citalopram (Celexa)

Citalopram (Tradename: Celexa) is a Selective Serotonin Reuptake Inhibitors (SSRI).

  • Felt that SERT-R is the cause of QTc prolongation in dose dependent fashion
  • Start at 10mg for 2 weeks, and increase to 20mg
  • Maximum dose 40mg daily (previously approved for up to 60 mg/day, but no longer due to QTc concerns)
  • The “cleanest” and most selective of the SSRIs, with minimal affinity for muscarinic, dopaminergic or norepinephrine receptors
  • Antihistamine likely contributes to more sedation, weight gain
  • May need HS dosing if too sedating

Citalopram is linked to QTc prolongation.

For Providers