Fluvoxamine (Luvox)

Pharmacokinetics of Fluvoxamine

Fluvoxamine: Cytochrome P450 Metabolism

Substrate of (Metabolized by)
Inhibits* 1A2, 2C19, 3A4 (potent)
  • σ1 antagonism may have some anxiolytic effects

Dosing for Fluvoxamine

Starting 50 mg, often split into BID dosing
Maximum 300 mg
  • Fluvoxamine comes in oral formulation.
  • If a patient is on theophylline, the dose needs to be reduced by 1/3, as fluvoxamine is a potent inhibitor of CYP1A2 (theophylline is metabolized by CYP1A2)
  • Fluvoxamine is almost exclusively used for OCD