- Last edited on February 20, 2021
Fluvoxamine (Luvox)
Primer
Fluvoxamine (Trade name: Luvox) is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class commonly used in the treatment of major depressive disorder and obsessive-compulsive disorder.
Pharmacokinetics
See also article: Introduction to Pharmacology
Pharmacokinetics of Fluvoxamine
See also article: Cytochrome (CYP) P450 Metabolism
Fluvoxamine: Cytochrome P450 Metabolism
Substrate of (Metabolized by) | |
---|---|
Induces | |
Inhibits* | 1A2, 2C19, 3A4 (potent) |
Pharmacodynamics
Mechanism of Action
- σ1 antagonism may have some anxiolytic effects
Toxicity
Indications
Dosing
Dosing for Fluvoxamine
Starting | 50 mg, often split into BID dosing |
---|---|
Titration | |
Maximum | 300 mg |
Taper |
Formulations
- Fluvoxamine comes in oral formulation.
Monitoring
Contraindications
Absolute
Relative
Drug-Drug Interactions
- If a patient is on theophylline, the dose needs to be reduced by 1/3, as fluvoxamine is a potent inhibitor of CYP1A2 (theophylline is metabolized by CYP1A2)
Side Effects
Adverse Events
Clinical Pearls
- Fluvoxamine is almost exclusively used for OCD
Special Populations
Geriatric
See main article: Geriatric Pharmacology
Pediatric
See main article: Pediatric Pharmacology
Obstetric and Fetal
See main article: Obstetric and Fetal Pharmacology
Medically Ill
See main article: Psychotropic Dosing in the Medically Ill