Quetiapine (Trade name: Seroquel) is an antipsychotic in the atypical antipsychotic class used in the treatment of schizophrenia, bipolar disorder, and major depressive disorder. It is also commonly used off-label for numerous other indications and psychiatric disorders.
Absorption | Tmax = 1-3 hours |
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Distribution | |
Metabolism | |
Elimination | |
Half-life | Half-life = 6-12 hours |
Substrate of (Metabolized by) | |
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Induces | |
Inhibits |
Generic name | Quetiapine Immediate Release (IR) | Quetiapine Extended Release (XR) |
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Tradename | Seroquel IR | Seroquel XR |
Dosage Strengths | 25 mg, 50 mg, 100 mg, 150 mg, 200 mg, 300 mg, 400 mg tablets | 50 mg, 150mg, 200mg, 300mg, 400mg tablets |
Half-life | Shorter | Longer |
Dosing | BID dosing | Once daily dosing |
Starting Dose (Bipolar Mania) | 50 mg BID (increase by 100-200 mg/day) | 300 mg PO daily (can increase by 300 mg/day) |
Target Dose (Bipolar Mania) | 400-800 mg PO daily[5] | 400-800 mg PO daily |
Advantages | May be more beneficial in acute mania and psychosis due to more sedating features | Faster dose titration and less sedating.[6] |
Disadvantages | More sedating | Lower side effect profile |