Desvenlafaxine (Pristiq)

Primer

Desvenlafaxine (Trade name: Pristiq) is an antidepressant in the serotonin norepinephrine reuptake inhibitor (SNRI) class used in the treatment of major depressive disorder.

Dosing

  • Starting dose: 50mg
  • Max dose: 100mg

Pearls

  • The elimination of desvenlafaxine is independent of CYP2D6 (unlike venlafaxine), which may be a potential advantage over venlafaxine for some patients in terms of drug–drug interactions and tolerability