Tranylcypromine (Parnate)

Tranylcypromine, trans-2-phenylcyclopropylamine (Tradename: Parnate) is a monoamine oxidase inhibitor (MAOI).

  • Peak plasma levels = 2.5 hours
  • Half life = 2 hours

Increasing doses of tranylcypromine can increase supine (lying flat) but not standing diastolic blood pressure.[1] Note that this is separate from the tyramine-induced hypertensive crisis that can occur in MAOIs.

  • The short half-life of tranylcypromine may be advantageous for use in older adults.