- Last edited on March 6, 2021
Oxcarbazepine (Trileptal)
Primer
Oxcarbazepine (Trade name: Trileptal) is a mood stabilizer and antiepileptic used in the treatment of epilepsy and bipolar disorder. It is generally better tolerated than carbamazepine.
Advantages
- Oxcarbazepine was developed due to several problems noticed in carbamazepine. Oxcarbazepine has the effectiveness as carbamazepine, but fewer problems, including:
- Minimal induction of cytochrome P450 enzymes
- No need for plasma level monitoring
- Much lower risk for agranulocytosis
- Lower risk for Stevens-Johnson Syndrome
- Less anticholinergic side effects such as dizziness, sedation and weight gain
- However, oxcarbazepine is more likely to cause hyponatremia compared to carbamazepine
Pharmacokinetics
See also article: Introduction to Pharmacology
Pharmacokinetics of Oxcarbazepine
See also article: Cytochrome (CYP) P450 Metabolism
Oxcarbazepine: Cytochrome P450 Metabolism
| Substrate of (Metabolized by) | |
|---|---|
| Induces | |
| Inhibits |
Pharmacodynamics
Mechanism of Action
Toxicity
Indications
Dosing
Dosing for Oxcarbazepine
| Starting | |
|---|---|
| Titration | |
| Maximum | |
| Taper |
Formulations
- Oxcarbazepine comes in
Monitoring
Contraindications
Absolute
Relative
Drug-Drug Interactions
Side Effects
Adverse Events
Clinical Pearls
Special Populations
Geriatric
See main article: Geriatric Pharmacology
Pediatric
See main article: Pediatric Pharmacology
Obstetric and Fetal
See main article: Obstetric and Fetal Pharmacology
Medically Ill
See main article: Psychotropic Dosing in the Medically Ill